反应详情

温度

60 °C

A suspension of N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-N′-phenylcyclopropane-1,1-dicarboxamide (960 mg, 1.87 mmol) in methyl ethyl ketone (9.6 mL) was stirred with heating at 60° C., and 6N hydrochloric acid was added. The mixture was cooled to room temperature and left standing for 20 hr. The precipitate was filtered and washed with methyl ethyl ketone to give the title compound (697 mg, 68%) as white crystals.

1. temperatureThe mixture was cooled to room temperature
2. waitleft
3. filtrationThe precipitate was filtered
4. washwashed with methyl ethyl ketone