Hydrochloric Acid → HCID 66968980, compound

HRID 2095894Notes

Reaction equation

HRID 2095894 reaction equation
[CH:1]1([C:4]([NH:6][C:7]2[N:8]=[C:9]3[CH:14]=[CH:13][C:12]([O:15][C:16]4[CH:21]=[CH:20][C:19]([NH:22][C:23]([C:25]5([C:28]([NH:30][C:31]6[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=6)=[O:29])[CH2:27][CH2:26]5)=[O:24])=[CH:18][C:17]=4[F:37])=[CH:11][N:10]3[CH:38]=2)=[O:5])[CH2:3][CH2:2]1.[ClH:39]>C(C(C)=O)C>[ClH:39].[CH:1]1([C:4]([NH:6][C:7]2[N:8]=[C:9]3[CH:14]=[CH:13][C:12]([O:15][C:16]4[CH:21]=[CH:20][C:19]([NH:22][C:23]([C:25]5([C:28]([NH:30][C:31]6[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=6)=[O:29])[CH2:26][CH2:27]5)=[O:24])=[CH:18][C:17]=4[F:37])=[CH:11][N:10]3[CH:38]=2)=[O:5])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58158470HCID 58158470, compound

Product 1

HCID 66968980HCID 66968980, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Conditions

Temperature
60 °C

Procedure

A suspension of N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-N′-phenylcyclopropane-1,1-dicarboxamide (960 mg, 1.87 mmol) in methyl ethyl ketone (9.6 mL) was stirred with heating at 60° C., and 6N hydrochloric acid was added. The mixture was cooled to room temperature and left standing for 20 hr. The precipitate was filtered and washed with methyl ethyl ketone to give the title compound (697 mg, 68%) as white crystals.

Workup

  1. temperatureThe mixture was cooled to room temperature
  2. waitleft
  3. filtrationThe precipitate was filtered
  4. washwashed with methyl ethyl ketone

Sources & evidence

ORD record
ord-5ea54df0fd024fd09c88bc4c5c7ea2c8
Source dataset
uspto-grants-2013_05
Patent number
US08445509B2

Reaction notes

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