反应详情

4-bromomethyl-4'-chlorobenzophenone (3.1 g) and sodium methanesulfinate (1.5 g) were added to N,N-dimethylformamide (50 ml), and the mixture was stirred for 16 hours at room temperature. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and dried over anhydrous magnesium sulfate. Ethyl acetate was distilled off under reduced pressure. The residual solid was washed with n-hexane to obtain the desired product (2.8 g, melting point: 164° to 166° C., yield: 90%).

1. extractionthe mixture was extracted with ethyl acetate
2. washThe ethyl acetate layer was washed with water
3. dry with materialdried over anhydrous magnesium sulfate
4. distillationEthyl acetate was distilled off under reduced pressure
5. washThe residual solid was washed with n-hexane