Triethyl phosphite → Diethyl P-((4-methoxyphenyl)methyl)phosphonate

HRID 2096099Notes

Reaction equation

HRID 2096099 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7]Cl)=[CH:5][CH:4]=1.[P:11]([O:18]CC)([O:15][CH2:16][CH3:17])[O:12][CH2:13][CH3:14]>>[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7][P:11](=[O:18])([O:15][CH2:16][CH3:17])[O:12][CH2:13][CH3:14])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 31215Triethyl phosphiteHCID 699934-Methyloxybenzyl chloride

Product 1

HCID 4063826Diethyl P-((4-methoxyphenyl)methyl)phosphonate

Procedure

4-methoxybenzylchloride and triethyl phosphite were reacted at 150° C. for 5 hours, followed by vacuum distillation for removal of excess triethyl phosphite and by-products to give diethyl 4-methoxybenzylphosphonate.

Workup

  1. distillationfollowed by vacuum distillation for removal of excess triethyl phosphite and by-products

Sources & evidence

ORD record
ord-987b99d28beb45e1b5b1817e903611ee
Source dataset
uspto-grants-2013_05
Patent number
US08450033B2

Reaction notes

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