Trifluoroacetic acid → HCID 57741178, compound

HRID 2096130Notes

Reaction equation

HRID 2096130 reaction equation
FC(F)(F)C(O)=O.C(OC([CH2:15][NH:16][CH:17]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[I:30])[C:18]([O:20][CH2:21][CH3:22])=[O:19])=O)(C)(C)C>C(Cl)Cl>[I:30][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1[CH2:23][CH:17]([NH:16][CH3:15])[C:18]([O:20][CH2:21][CH3:22])=[O:19]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68534124HCID 68534124, compound

Product 1

HCID 57741178HCID 57741178, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (25 ml) was added to ethyl 2-(tert-butoxycarbonylmethylamino)-3-(2-iodophenyl)propionate (6.4 g, 15 mmol) in CH2Cl2 (35 ml). The mixture was stirred at room temperature for 2 h. The reaction solution was concentrated on a rotary evaporator, the residue was taken up in ethyl acetate, washed (NaHCO3 sat.), dried and concentrated The residue obtained in this manner (3.9 g, 79%) was reacted further as a crude product.

Workup

  1. concentrationThe reaction solution was concentrated on a rotary evaporator
  2. washwashed (NaHCO3 sat.)
  3. customdried
  4. concentrationconcentrated The residue
  5. customobtained in this manner (3.9 g, 79%)

Sources & evidence

ORD record
ord-da0fc6cd4f25448db48c30b78aa969f2
Source dataset
uspto-grants-2013_05
Patent number
US08450301B2

Reaction notes

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