1,4-Dioxaspiro[4.5]decan-8-one → 8-(6-Fluoropyridin-3-yl)-1,4-dioxaspiro[4.5]decan-8-ol

HRID 2096148Notes

Reaction equation

HRID 2096148 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([F:8])=[N:6][CH:7]=1.[O:9]1[C:13]2([CH2:18][CH2:17][C:16](=[O:19])[CH2:15][CH2:14]2)[O:12][CH2:11][CH2:10]1>CCOCC>[F:8][C:5]1[N:6]=[CH:7][C:2]([C:16]2([OH:19])[CH2:17][CH2:18][C:13]3([O:12][CH2:11][CH2:10][O:9]3)[CH2:14][CH2:15]2)=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 5674151,4-Dioxaspiro[4.5]decan-8-oneHCID 27831685-Bromo-2-fluoropyridine

Product 1

HCID 595560478-(6-Fluoropyridin-3-yl)-1,4-dioxaspiro[4.5]decan-8-ol

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound was prepared as a white solid from 5-bromo-2-fluoro-pyridine (Aldrich) and 1,4-dioxa-spiro[4.5]decan-8-one in ether using the procedure described in Step A of Example 1.

Sources & evidence

ORD record
ord-b89eb276f64e4d0f8a349c5e7dce16ed
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

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