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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2096148Generated: October 31, 2026

1,4-Dioxaspiro[4.5]decan-8-one → 8-(6-Fluoropyridin-3-yl)-1,4-dioxaspiro[4.5]decan-8-ol

https://huagongshe.com/reaction/2096148

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dioxaspiro[4.5]decan-8-oneHCID 567415—
Reactant5-Bromo-2-fluoropyridineHCID 2783168—
SolventDiethyl EtherHCID 3283—
Product8-(6-Fluoropyridin-3-yl)-1,4-dioxaspiro[4.5]decan-8-olHCID 59556047—

Reaction Steps

The title compound was prepared as a white solid from 5-bromo-2-fluoro-pyridine (Aldrich) and 1,4-dioxa-spiro[4.5]decan-8-one in ether using the procedure described in Step A of Example 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08450304B2
Source datasetuspto-grants-2013_05
ORD IDord-b89eb276f64e4d0f8a349c5e7dce16ed
Source noteuspto-grants-2013_05