2,2,2-Trifluoroethanol → HCID 71452241, compound

HRID 2096154Notes

Reaction equation

HRID 2096154 reaction equation
F[C:2]1[N:7]=[CH:6][C:5]([C:8]2([OH:35])[CH2:13][CH2:12][CH:11]([N:14]3[CH2:17][CH:16]([NH:18][C:19]([CH2:21][NH:22][C:23](=[O:34])[C:24]4[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[CH:25]=4)=[O:20])[CH2:15]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[C:36]([CH2:40][OH:41])([F:39])([F:38])[F:37]>>[OH:35][C:8]1([C:5]2[CH:6]=[N:7][C:2]([O:41][CH2:40][C:36]([F:39])([F:38])[F:37])=[CH:3][CH:4]=2)[CH2:13][CH2:12][CH:11]([N:14]2[CH2:15][CH:16]([NH:18][C:19]([CH2:21][NH:22][C:23](=[O:34])[C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:32])([F:31])[F:33])[CH:25]=3)=[O:20])[CH2:17]2)[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 64092,2,2-TrifluoroethanolHCID 46241719HCID 46241719, compound

Product 1

HCID 71452241HCID 71452241, compound

Procedure

The title compound was prepared as a white solid from N-({1-[4-(6-fluoro-pyridin-3-yl)-4-hydroxy-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide 6a and CF3CH2OH (Sigma) using the procedure described in Example 8.

Sources & evidence

ORD record
ord-ad5d8835f4e3447db01f2a3adfb8f802
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

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