1,3-Benzodioxole-5-carbonyl chloride → HCID 46241830, compound

HRID 2096167Notes

Reaction equation

HRID 2096167 reaction equation
[NH2:1][CH2:2][C:3]([NH:5][CH:6]1[CH2:9][N:8]([CH:10]2[CH2:15][CH2:14][C:13]([OH:24])([C:16]3[CH:17]=[N:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=3)[CH2:12][CH2:11]2)[CH2:7]1)=[O:4].[C:25](Cl)(=[O:35])[C:26]1[CH:34]=[CH:33][C:32]2[O:31][CH2:30][O:29][C:28]=2[CH:27]=1>>[OH:24][C:13]1([C:16]2[CH:17]=[N:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=2)[CH2:14][CH2:15][CH:10]([N:8]2[CH2:9][CH:6]([NH:5][C:3]([CH2:2][NH:1][C:25]([C:26]3[CH:34]=[CH:33][C:32]4[O:31][CH2:30][O:29][C:28]=4[CH:27]=3)=[O:35])=[O:4])[CH2:7]2)[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 27347491,3-Benzodioxole-5-carbonyl chlorideHCID 593615572-amino-N-{1-[4-hydroxy-4-(6-methoxy-pyridin-3-yl)-cyclohexyl]-azetidin-3-yl}-acetamide

Product 1

HCID 46241830HCID 46241830, compound

Procedure

The title compound was prepared as yellow solid from coupling of 2-amino-N-{1-[4-hydroxy-4-(6-methoxy-pyridin-3-yl)-cyclohexyl]-azetidin-3-yl}-acetamide, as prepared in Step D of Example 16, and piperonoyl chloride (Aldrich) using the procedure described in Example 18.

Sources & evidence

ORD record
ord-eda09f29eb754e06a1c2d5be9cdf462c
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

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