Trifluoroacetic acid → HCID 46240787, compound

HRID 2096211Notes

Reaction equation

C(O)(C(F)(F)F)=O.C(OC(=O)[NH:14][C:15]1[S:16][C:17]([C:20]2([OH:47])[CH2:25][CH2:24][CH:23]([N:26]3[CH2:29][CH:28]([NH:30][C:31](=[O:46])[CH2:32][NH:33][C:34](=[O:45])[C:35]4[CH:40]=[CH:39][CH:38]=[C:37]([C:41]([F:44])([F:43])[F:42])[CH:36]=4)[CH2:27]3)[CH2:22][CH2:21]2)=[CH:18][N:19]=1)(C)(C)C>>[NH2:14][C:15]1[S:16][C:17]([C:20]2([OH:47])[CH2:25][CH2:24][CH:23]([N:26]3[CH2:29][CH:28]([NH:30][C:31]([CH2:32][NH:33][C:34](=[O:45])[C:35]4[CH:40]=[CH:39][CH:38]=[C:37]([C:41]([F:43])([F:44])[F:42])[CH:36]=4)=[O:46])[CH2:27]3)[CH2:22][CH2:21]2)=[CH:18][N:19]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 59361630HCID 59361630, compound

Product 1

HCID 46240787HCID 46240787, compound

Procedure

The title compound was prepared as colorless oil from TFA de-protection of [5-(1-hydroxy-4-{3-[2-(3-trifluoromethyl-benzoylamino)-acetylamino]-azetidin-1-yl}-cyclohexyl)-thiazol-2-yl]-carbamic acid tert-butyl ester, as prepared in the previous step, using the procedure described in Step B of Example 16.

Workup

customas prepared in the previous step

Sources & evidence

ORD record: ord-da3c23b5dbde498b9634ebcda66ca005
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08450304B2

Reaction notes

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