Pyrrolidine → HCID 46240894, compound

HRID 2096213Notes

Reaction equation

[OH:1][C:2]1([C:29]2[S:33][C:32](S(C)(=O)=O)=[N:31][CH:30]=2)[CH2:7][CH2:6][CH:5]([N:8]2[CH2:11][CH:10]([NH:12][C:13]([CH2:15][NH:16][C:17](=[O:28])[C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=3)=[O:14])[CH2:9]2)[CH2:4][CH2:3]1.[NH:38]1[CH2:42][CH2:41][CH2:40][CH2:39]1>>[OH:1][C:2]1([C:29]2[S:33][C:32]([N:38]3[CH2:42][CH2:41][CH2:40][CH2:39]3)=[N:31][CH:30]=2)[CH2:7][CH2:6][CH:5]([N:8]2[CH2:9][CH:10]([NH:12][C:13]([CH2:15][NH:16][C:17](=[O:28])[C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:25])([F:26])[F:27])[CH:19]=3)=[O:14])[CH2:11]2)[CH2:4][CH2:3]1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 46240784HCID 46240784, compound

Product 1

HCID 46240894HCID 46240894, compound

Procedure

The title compound was prepared as a white solid from N-({1-[4-hydroxy-4-(2-methanesulfonyl-thiazol-5-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide (less polar isomer, 47a), and pyrrolidine (Aldrich) using the procedure described in Example 50.

Sources & evidence

ORD record: ord-09a5f4e69fb049fd98b73826f88f5e69
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08450304B2

Reaction notes

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