Isothiazole → 8-Isothiazol-5-yl-1,4-dioxa-spiro[4.5]decan-8-ol

HRID 2096220Notes

Reaction equation

HRID 2096220 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[N:2]1.[O:6]1[C:10]2([CH2:15][CH2:14][C:13](=[O:16])[CH2:12][CH2:11]2)[O:9][CH2:8][CH2:7]1>>[S:1]1[C:5]([C:13]2([OH:16])[CH2:14][CH2:15][C:10]3([O:9][CH2:8][CH2:7][O:6]3)[CH2:11][CH2:12]2)=[CH:4][CH:3]=[N:2]1

Participants

3

Reactant 2

HCID 67515IsothiazoleHCID 5674151,4-Dioxaspiro[4.5]decan-8-one

Product 1

HCID 593615918-Isothiazol-5-yl-1,4-dioxa-spiro[4.5]decan-8-ol

Procedure

The title compound was prepared as a white solid from isothiazole (Focus Synthesis) and 1,4-dioxa-spiro[4.5]decan-8-one using the procedure described in Step A of Example 33.

Sources & evidence

ORD record
ord-f9163bee0dc24103bb1ba65913e5710f
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

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