4-Hydroxy-4-thiazol-2-yl-cyclohexanone → N-{[1-(4-Hydroxy-4-thiazol-2-yl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-2,5-bis-trifluoromethyl-benzamide

HRID 2096238Notes

Reaction equation

HRID 2096238 reaction equation
[OH:1][C:2]1([C:9]2[S:10][CH:11]=[CH:12][N:13]=2)[CH2:7][CH2:6][C:5](=O)[CH2:4][CH2:3]1.[NH:14]1[CH2:17][CH:16]([NH:18][C:19]([CH2:21][NH:22][C:23](=[O:38])[C:24]2[CH:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[CH:26][C:25]=2[C:34]([F:37])([F:36])[F:35])=[O:20])[CH2:15]1>>[OH:1][C:2]1([C:9]2[S:10][CH:11]=[CH:12][N:13]=2)[CH2:7][CH2:6][CH:5]([N:14]2[CH2:17][CH:16]([NH:18][C:19]([CH2:21][NH:22][C:23](=[O:38])[C:24]3[CH:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[CH:26][C:25]=3[C:34]([F:35])([F:37])[F:36])=[O:20])[CH2:15]2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 590174374-Hydroxy-4-thiazol-2-yl-cyclohexanoneHCID 59361598N-(azetidin-3-ylcarbamoylmethyl)-2,5-bis-trifluoromethyl-benzamide

Product 1

HCID 46241219N-{[1-(4-Hydroxy-4-thiazol-2-yl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-2,5-bis-trifluoromethyl-benzamide

Procedure

The title compound was prepared as white solids from reductive amination of 4-hydroxy-4-thiazol-2-yl-cyclohexanone, as prepared in Example 40 Step B, and N-(azetidin-3-ylcarbamoylmethyl)-2,5-bis-trifluoromethyl-benzamide using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-28733cc33a044203bbbf695a01d76587
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

Loading…