HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxy-4-thiazol-2-yl-cyclohexanone → N-{[1-(4-Hydroxy-4-thiazol-2-yl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-2,5-bis-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxy-4-thiazol-2-yl-cyclohexanone | HCID 59017437 | — |
| Reactant | N-(azetidin-3-ylcarbamoylmethyl)-2,5-bis-trifluoromethyl-benzamide | HCID 59361598 | — |
| Product | N-{[1-(4-Hydroxy-4-thiazol-2-yl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-2,5-bis-trifluoromethyl-benzamide | HCID 46241219 | — |
Reaction Steps
The title compound was prepared as white solids from reductive amination of 4-hydroxy-4-thiazol-2-yl-cyclohexanone, as prepared in Example 40 Step B, and N-(azetidin-3-ylcarbamoylmethyl)-2,5-bis-trifluoromethyl-benzamide using the procedure described in Step E of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450304B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-28733cc33a044203bbbf695a01d76587 |
| Source note | uspto-grants-2013_05 |