HCID 59361627, compound → 2-Chloro-N-({1-[4-hydroxy-4-(6-methyl-pyridin-3-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-5-trifluoromethyl-benzamide

HRID 2096241Notes

Reaction equation

HRID 2096241 reaction equation
[OH:1][C:2]1([C:9]2[CH:10]=[N:11][C:12]([CH3:15])=[CH:13][CH:14]=2)[CH2:7][CH2:6][C:5](=O)[CH2:4][CH2:3]1.[NH:16]1[CH2:19][CH:18]([NH:20][C:21]([CH2:23][NH:24][C:25](=[O:37])[C:26]2[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:29]=[CH:28][C:27]=2[Cl:36])=[O:22])[CH2:17]1>>[Cl:36][C:27]1[CH:28]=[CH:29][C:30]([C:32]([F:35])([F:33])[F:34])=[CH:31][C:26]=1[C:25]([NH:24][CH2:23][C:21](=[O:22])[NH:20][CH:18]1[CH2:19][N:16]([CH:5]2[CH2:6][CH2:7][C:2]([OH:1])([C:9]3[CH:10]=[N:11][C:12]([CH3:15])=[CH:13][CH:14]=3)[CH2:3][CH2:4]2)[CH2:17]1)=[O:37]

Participants

3

Reactant 2

HCID 59361627HCID 59361627, compoundHCID 59361638N-(azetidin-3-ylcarbamoylmethyl)-2-chloro-5-trifluoromethyl-benzamide

Product 1

HCID 462413222-Chloro-N-({1-[4-hydroxy-4-(6-methyl-pyridin-3-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-5-trifluoromethyl-benzamide

Procedure

The title compounds were prepared as white solids from reductive amination of 4-hydroxy-4-(6-methyl-pyridin-3-yl)-cyclohexanone, as prepared in Example 13 Step B, and N-(azetidin-3-ylcarbamoylmethyl)-2-chloro-5-trifluoromethyl-benzamide using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-e35efa01a4774021a8c7f42e591716cd
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

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