Sodium Hydroxide → HCID 67441261, compound

HRID 2096272Notes

Reaction equation

HRID 2096272 reaction equation
[CH3:1][O:2][C:3]1[CH:47]=[C:46]([O:48][CH3:49])[CH:45]=[CH:44][C:4]=1[CH2:5][N:6]1[CH:11]=[C:10]([CH2:12][C:13]2[CH:14]=[CH:15][C:16]([F:21])=[C:17]([CH:20]=2)[C:18]#[N:19])[N:9]2[CH:22]=[C:23]([C:25]3[C:33]4[C:28](=[N:29][CH:30]=[CH:31][CH:32]=4)[N:27](S(C4C=CC=CC=4)(=O)=O)[CH:26]=3)[CH:24]=[C:8]2[C:7]1=[O:43].[OH-].[Na+]>O1CCOCC1.O>[CH3:1][O:2][C:3]1[CH:47]=[C:46]([O:48][CH3:49])[CH:45]=[CH:44][C:4]=1[CH2:5][N:6]1[CH:11]=[C:10]([CH2:12][C:13]2[CH:14]=[CH:15][C:16]([F:21])=[C:17]([CH:20]=2)[C:18]#[N:19])[N:9]2[CH:22]=[C:23]([C:25]3[C:33]4[C:28](=[N:29][CH:30]=[CH:31][CH:32]=4)[NH:27][CH:26]=3)[CH:24]=[C:8]2[C:7]1=[O:43]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 67443640HCID 67443640, compound

Product 1

HCID 67441261HCID 67441261, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of EXAMPLE 2A (90 mg, 0.13 mmol) in dioxane (10 ml) was added NaOH (52 mg, 1.3 mmol) in water (1 ml). The mixture was heated at 50° C. overnight, and partitioned between ethyl acetate and water. The organic phase was concentrated to afford the title compound. MS (DCI/NH3) m/z 534 (M+H)+.

Workup

  1. custompartitioned between ethyl acetate and water
  2. concentrationThe organic phase was concentrated

Sources & evidence

ORD record
ord-20751c701d13400d830321c6f8ecd46c
Source dataset
uspto-grants-2013_05
Patent number
US08450320B2

Reaction notes

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