Hydrochloric Acid → HCID 67307048, compound

HRID 2096297Notes

Reaction equation

HRID 2096297 reaction equation
CO.[F:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C@H:11]1[CH2:15][CH2:14][CH2:13][N:12]1[C:16]1[CH:17]=[CH:18][C:19]2[N:20]([C:22]([NH:25][C:26]([N:28]3[CH2:32][CH2:31][C@H:30]([OH:33])[CH2:29]3)=[O:27])=[CH:23][N:24]=2)[N:21]=1.[ClH:34]>O1CCOCC1>[ClH:34].[F:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C@H:11]1[CH2:15][CH2:14][CH2:13][N:12]1[C:16]1[CH:17]=[CH:18][C:19]2[N:20]([C:22]([NH:25][C:26]([N:28]3[CH2:32][CH2:31][C@H:30]([OH:33])[CH2:29]3)=[O:27])=[CH:23][N:24]=2)[N:21]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 45274003HCID 45274003, compound

Product 1

HCID 67307048HCID 67307048, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a methanol (1 mL) solution of (S)—N-(6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-3-hydroxypyrrolidine-1-carboxamide (10.1 mg, 0.0236 mmol) was added HCl as a solution is dioxane (30 μL). After minutes, the reaction was concentrated to provide (S)—N-(6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrochloride as a yellow solid.

Workup

  1. waitAfter minutes
  2. concentrationthe reaction was concentrated

Sources & evidence

ORD record
ord-6370382be6ed450284b429bf4ece980e
Source dataset
uspto-grants-2013_05
Patent number
US08450322B2

Reaction notes

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