Hydrochloric Acid → HCID 45274024, compound

HRID 2096301Notes

Reaction equation

HRID 2096301 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[C:14]1[CH:15]=[CH:16][C:17]2[N:18]([C:20]([NH:23][C:24]([N:26]3[CH2:31][CH2:30][CH2:29][CH:28]([NH:32]C(=O)OC(C)(C)C)[CH2:27]3)=[O:25])=[CH:21][N:22]=2)[N:19]=1.[ClH:40]>C(Cl)Cl>[ClH:40].[NH2:32][CH:28]1[CH2:29][CH2:30][CH2:31][N:26]([C:24]([NH:23][C:20]2[N:18]3[N:19]=[C:14]([N:10]4[CH2:11][CH2:12][CH2:13][C@@H:9]4[C:3]4[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=4[F:1])[CH:15]=[CH:16][C:17]3=[N:22][CH:21]=2)=[O:25])[CH2:27]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58334502HCID 58334502, compound

Product 1

HCID 45274024HCID 45274024, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 1-(6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-ylcarbamoyl)piperidin-3-ylcarbamate (Example 17; 10 mg, 0.018 mmol) was dissolved in 0.1 mL DCM, followed by addition of 0.5 mL 4 N HCl (dioxane) solution in one portion. After stirring at ambient temperature overnight, the reaction was concentrated to yield the final product salt form as a light yellowish solid. MS (apci) m/z=442.1 (M+H).

Workup

  1. concentrationthe reaction was concentrated

Sources & evidence

ORD record
ord-20b5079e1f6f4623aea12d16b48d4331
Source dataset
uspto-grants-2013_05
Patent number
US08450322B2

Reaction notes

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