Hydrochloric Acid → HCID 67308037, compound

HRID 2096303Notes

Reaction equation

HRID 2096303 reaction equation
CO.[F:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C@H:11]1[CH2:15][CH2:14][CH2:13][N:12]1[C:16]1[CH:17]=[CH:18][C:19]2[N:20]([C:22]([NH:25][C:26]([N:28]3[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]3)=[O:27])=[CH:23][N:24]=2)[N:21]=1.[ClH:34]>O1CCOCC1>[ClH:34].[F:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C@H:11]1[CH2:15][CH2:14][CH2:13][N:12]1[C:16]1[CH:17]=[CH:18][C:19]2[N:20]([C:22]([NH:25][C:26]([N:28]3[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]3)=[O:27])=[CH:23][N:24]=2)[N:21]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 58334520HCID 58334520, compound

Product 1

HCID 67308037HCID 67308037, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a methanol (1 mL) solution of (R)—N-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)piperidine-1-carboxamide (4.9 mg, 0.011 mmol) was added HCl as a solution is dioxane (30 μL). After 30 minutes, the reaction was concentrated to provide (R)—N-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)piperidine-1-carboxamide hydrochloride (4.2 mg, 0.0091 mmol, 79% yield) as a yellow solid. MS (apci) m/z=427.4 (M+H).

Workup

  1. concentrationthe reaction was concentrated

Sources & evidence

ORD record
ord-5f6c38b6a17040ba80d5841b06f1a3c7
Source dataset
uspto-grants-2013_05
Patent number
US08450322B2

Reaction notes

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