Hydrochloric Acid → HCID 67306676, compound

HRID 2096305Notes

Reaction equation

HRID 2096305 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[C:14]1[CH:15]=[CH:16][C:17]2[N:18]([C:20]([NH:23][C:24]([N:26]3[CH2:31][CH2:30][N:29](C(OC(C)(C)C)=O)[C@H:28]([CH3:39])[CH2:27]3)=[O:25])=[CH:21][N:22]=2)[N:19]=1.[ClH:40]>>[ClH:40].[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[C:14]1[CH:15]=[CH:16][C:17]2[N:18]([C:20]([NH:23][C:24]([N:26]3[CH2:31][CH2:30][NH:29][C@H:28]([CH3:39])[CH2:27]3)=[O:25])=[CH:21][N:22]=2)[N:19]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 45274051HCID 45274051, compound

Product 1

HCID 67306676HCID 67306676, compound

Procedure

To a reaction vial containing (R)-tert-butyl 4-(6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-1)]pyridazin-3-ylcarbamoyl)-2-methylpiperazine-1-carboxylate (Example 36; 12 mg, 0.022 mmol) was added 0.5 mL 4 N HCl (dioxane) solution in one portion. After stirring at ambient temperature for 4 hours, the reaction was concentrated. The resulting solid residue was treated with ether and concentrated again to yield the final product salt form as a pale-yellowish powder. MS (apci) m/z=442.2 (M+H).

Workup

  1. concentrationthe reaction was concentrated
  2. additionThe resulting solid residue was treated with ether
  3. concentrationconcentrated again

Sources & evidence

ORD record
ord-901d9d3024124a5a89a8da66ad31cde9
Source dataset
uspto-grants-2013_05
Patent number
US08450322B2

Reaction notes

Loading…