Dichloromethane → tert-Butyl 4-(2-(4-(2-fluoro-4-(3-(2-(4-fluorophenyl)acetyl)ureido)phenoxy)pyridin-3-yl)ethynyl)cyclohex-3-enylcarbamate
Reaction equation
[CH3:45][O:46][c:47]1[cH:48][cH:49][c:50]([CH2:51][NH:52][c:53]2[n:54][cH:55][n:56][c:57]([O:58][c:59]3[cH:60][cH:61][c:62]([NH:63][C:64]([NH:65][C:66](=[O:67])[CH2:68][c:69]4[cH:70][cH:71][c:72]([F:73])[cH:74][cH:75]4)=[O:76])[cH:77][c:78]3[F:79])[cH:80]2)[cH:81][cH:82]1.[Cl:83][CH2:84][Cl:85].[F:32][c:33]1[cH:34][cH:35][c:36]([CH2:39][C:40](=[O:41])[N:42]=[C:43]=[O:44])[cH:37][cH:38]1.[NH2:1][c:2]1[cH:3][c:4]([F:31])[c:5]([O:6][c:7]2[c:8]([C:13]#[C:14][C:15]3=[CH:16][CH2:17][CH:18]([NH:21][C:22]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:28])[CH2:19][CH2:20]3)[cH:9][n:10][cH:11][cH:12]2)[cH:29][cH:30]1>>[NH:1]([c:2]1[cH:3][c:4]([F:31])[c:5]([O:6][c:7]2[c:8]([C:13]#[C:14][C:15]3=[CH:16][CH2:17][CH:18]([NH:21][C:22]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:28])[CH2:19][CH2:20]3)[cH:9][n:10][cH:11][cH:12]2)[cH:29][cH:30]1)[C:43]([NH:42][C:40]([CH2:39][c:36]1[cH:35][cH:34][c:33]([F:32])[cH:38][cH:37]1)=[O:41])=[O:44]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-ef83b684938c4322a3b0edf7b62b304f
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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