5-Bromo-2-phenylpyrimidine → phenyl(5-(2-(pyridin-3-yl)-1H-imidazol-5-yl)pyrimidin-2-yl)methanone

HRID 2096351Notes

Reaction equation

HRID 2096351 reaction equation
Br[C:2]1[CH:3]=[N:4][C:5]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])=[N:6][CH:7]=1.BrC1C=NC(C2C=CC=CC=2)=NC=1.C([N:36]1[CH:40]=[CH:39][N:38]=[C:37]1[C:41]1[CH:42]=[N:43][CH:44]=[CH:45][CH:46]=1)C1C=CC=CC=1>>[C:10]1([C:8]([C:5]2[N:4]=[CH:3][C:2]([C:40]3[NH:36][C:37]([C:41]4[CH:42]=[N:43][CH:44]=[CH:45][CH:46]=4)=[N:38][CH:39]=3)=[CH:7][N:6]=2)=[O:9])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 3

HCID 143877455-Bromo-2-phenylpyrimidineHCID 67360359(5-Bromo-pyrimidine-2-yl)-phenyl-methanoneHCID 673615683-(1-benzyl-1H-imidazol-2-yl)pyridine

Product 1

HCID 59252386phenyl(5-(2-(pyridin-3-yl)-1H-imidazol-5-yl)pyrimidin-2-yl)methanone

Procedure

The title compound is prepared by the method described in Example 1, except that (5-bromopyrimidin-2-yl)(phenyl)methanone (prepared according to the procedure described in WO 2008/121670 p. 94) is used instead of 5-bromo-2-phenylpyrimidine and 3-(1-benzyl-1H-imidazol-2-yl)pyridine is used instead of 1-benzyl-2-phenyl-1H-imidazole in Step C.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-70eebdc67b8a4233a8d29db87f518dba
Source dataset
uspto-grants-2013_05
Patent number
US08450326B2

Reaction notes

Loading…