反应详情

A solution of 2-tert-butyldimethylsilyloxymethyl-6-(1-methoxy-1-methylethyl)pyridine (1.20 g, 4.08 mmol) in AcOH (45 mL), THF (15 mL) and H2O (15 mL) was stirred for 48 h at room temperature. The solvent was removed in vacuo, the residue was partitioned between DCM and sat aq NaHCO3, the organic portion was separated, dried (MgSO4), filtered and evaporated to give the title compound (740 mg, 100%) as a colourless oil; NMR δH (400 MHz, CDCl3) 7.70-7.66 (1H, m), 7.48-7.45 (1H, m), 7.07-7.04 (1H, m), 4.74 (2H, d, J 5.0 Hz), 4.14 (1H, t, J 5.0 Hz), 3.18 (3H, s), 1.57 (6H, s).

1. customThe solvent was removed in vacuo
2. customthe residue was partitioned between DCM
3. customthe organic portion was separated
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. customevaporated