Methyl iodide → HCID 66697304, compound

HRID 2096836Notes

Reaction equation

HRID 2096836 reaction equation
[F:1][C:2]1[C:12]([C:13]#[N:14])=[CH:11][C:5]2[NH:6][C:7](=[O:10])[CH2:8][O:9][C:4]=2[CH:3]=1.[CH3:15]C([O-])(C)C.[K+].CI>CN(C)C(=O)C>[F:1][C:2]1[C:12]([C:13]#[N:14])=[CH:11][C:5]2[N:6]([CH3:15])[C:7](=[O:10])[CH2:8][O:9][C:4]=2[CH:3]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 21873814HCID 21873814, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 66697304HCID 66697304, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

To a stirred solution of 7-fluoro-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonitrile (CAS Reg. No. [151982-49-9], 4.71 g) in N,N-dimethylacetamide (108 ml) were added KOtBu (3.08 g) and methyl iodide (3.83 g). The mixture was stirred at room temperature for 3.5 h. Ice water was added. The suspension was filtered and the solid was washed with water and dried to give the title compound (4.07 g) as an off-white solid.

Workup

  1. filtrationThe suspension was filtered
  2. washthe solid was washed with water
  3. customdried

Sources & evidence

ORD record
ord-9dc2b738467f41798f351184fda28232
Source dataset
uspto-grants-2013_05
Patent number
US08450313B2

Reaction notes

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