Water → HCID 58154286, compound

HRID 2096981Notes

Reaction equation

HRID 2096981 reaction equation
O.[NH2:2][NH2:3].F[C:5]1[C:12]([I:13])=[C:11]([CH3:14])[CH:10]=[CH:9][C:6]=1[C:7]#[N:8].O>C(O)C>[I:13][C:12]1[C:11]([CH3:14])=[CH:10][CH:9]=[C:6]2[C:5]=1[NH:3][N:2]=[C:7]2[NH2:8]

Participants

5

Reactant 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 593838982-Fluoro-3-iodo-4-methylbenzonitrile

Product 1

HCID 58154286HCID 58154286, compoundYield 87.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

A solution of hydrazine monohydrate (0.56 mL, 11.6 mmol) and 2-fluoro-3-iodo-4-methylbenzonitrile (WO2006094187, 1.00 g, 3.8 mmol) in ethanol (7 mL) was stirred and heated to 100° C. in a sealed tube. After stirring overnight, the mixture was cooled and water was added. The resultant precipitate was filtered, washed with water and hexanes, and then dried in vacuo to give the title compound (0.91 g, 87%) as a yellow solid.

Workup

  1. temperaturethe mixture was cooled
  2. filtrationThe resultant precipitate was filtered
  3. washwashed with water and hexanes
  4. customdried in vacuo

Sources & evidence

ORD record
ord-4bdbc1d944b847a397ee9b6f0800f26f
Source dataset
uspto-grants-2013_05
Patent number
US08450341B2

Reaction notes

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