反应详情

A mixture of 2-chloro-3-iodo-4-methylpyridine (preparation 28a, 2.0 g, 7.9 mmol) and hydrazine hydrate (1.2 mL, 24.2 mmol) in pyridine (12 mL) under an argon atmosphere was stirred and heated to reflux. After 24 hours, the mixture was cooled and evaporated to dryness. The crude mixture was triturated with water and the solid was filtered and washed with water to give the title compound (1.71 g, 87%) which was used without further purification in the next reaction.

1. temperatureheated to reflux
2. temperaturethe mixture was cooled
3. customevaporated to dryness
4. customThe crude mixture was triturated with water
5. filtrationthe solid was filtered
6. washwashed with water