Hydrochloric Acid → HCID 66905804, compound

HRID 2097228Notes

Reaction equation

HRID 2097228 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12](=[O:28])[CH:13]([C:23]3[CH:27]=[CH:26][S:25][CH:24]=3)[CH2:14][NH:15]C(=O)OC(C)(C)C)=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.[ClH:29]>C(Cl)Cl>[ClH:29].[ClH:29].[NH2:15][CH2:14][CH:13]([C:23]1[CH:27]=[CH:26][S:25][CH:24]=1)[C:12]([NH:11][C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[CH:1]=[N:2][CH:3]=[CH:4]2)=[O:28]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59161745HCID 59161745, compound

Product 1

HCID 66905804HCID 66905804, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(thiophen-3-yl)propylcarbamate (E48) in CH2Cl2 was added HCl (4N in dioxane), and the solution was stirred for 8-10 hours. The solvents were evaporated to give pure 3-amino-N-(isoquinolin-6-yl)-2-(thiophen-3-yl)propanamide dihydrochloride (E49).

Workup

  1. customThe solvents were evaporated

Sources & evidence

ORD record
ord-d9f43c4e48b14499ba109df8d7e75883
Source dataset
uspto-grants-2013_05
Patent number
US08450344B2

Reaction notes

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