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HRID2097236

反应详情

EQUATION

反应方程式

HRID 2097236 的结构方程式

REACTANTS

反应物

3
结构：NC=O
HCID713

Formamide

CH3NO

结构：C[O-].[Na+]
HCID10942334

Methanol, sodium salt

CH3NaO

结构：COC(=O)c1ccc(NC(=O)C(c2ccsc2)N(C)C)cc1
HCID59161754

未命名化合物

PRODUCTS

生成物

1
结构：CN(C)C(C(=O)Nc1ccc(C(N)=O)cc1)c1ccsc1
HCID46184604

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度
100 °C

PROCEDURE

实验过程

Methyl 4-(2-(dimethylamino)-2-(thiophen-3-yl)acetamido)benzoate (E114) and formamide dissolved in DMF under Ar were heated to 100° C. The NaOMe was then added and the reaction heated for 2 hours. The reaction was partitioned between EtOAc and water. The aqueous layer was extracted with EtOAc. The extracts were dried (MgSO4), filtered and evaporated. Column chromatography (SiO2, 0-100% EtOAc/Hex) gave pure 4-(2-(dimethylamino)-2-(thiophen-3-yl)acetamido)benzamide (E115).

WORKUP

后处理

  1. temperaturethe reaction heated for 2 hours
  2. customThe reaction was partitioned between EtOAc and water
  3. extractionThe aqueous layer was extracted with EtOAc
  4. dry with materialThe extracts were dried (MgSO4)
  5. filtrationfiltered
  6. customevaporated