HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 1-(2,4-Bis-benzyloxy-5-isobutyl-phenyl)-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(2,4-Dihydroxy-5-isobutyl-phenyl)-ethanone | HCID 59264780 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(2,4-Bis-benzyloxy-5-isobutyl-phenyl)-ethanone | HCID 24774607 | — |
Reaction Conditions
| Temperature | 150 °C |
|---|
Reaction Steps
1-(2,4-Dihydroxy-5-isobutyl-phenyl)-ethanone (1 eq) was dissolved in DMF and potassium carbonate (4.4 eq) then benzyl bromide (4.4 eq) was added. The suspension was heated, with stirring to 150° C., under nitrogen, for 16 hrs. The solution was cooled to room temperature, filtered and concentrated to dryness. This solid was purified column chromatography (silica, hexanes:ethyl acetate 4:1) then re-crystallised from ethyl acetate:hexanes to give 1-(2,4-Bis-benzyloxy-5-isobutyl-phenyl)-ethanone as colourless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450310B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-d71938481c4344959bb55f7955490e59 |
| Source note | uspto-grants-2013_05 |