反应详情

温度

150 °C

1-(2,4-Dihydroxy-5-isobutyl-phenyl)-ethanone (1 eq) was dissolved in DMF and potassium carbonate (4.4 eq) then benzyl bromide (4.4 eq) was added. The suspension was heated, with stirring to 150° C., under nitrogen, for 16 hrs. The solution was cooled to room temperature, filtered and concentrated to dryness. This solid was purified column chromatography (silica, hexanes:ethyl acetate 4:1) then re-crystallised from ethyl acetate:hexanes to give 1-(2,4-Bis-benzyloxy-5-isobutyl-phenyl)-ethanone as colourless crystals.

1. temperatureThe suspension was heated
2. temperatureThe solution was cooled to room temperature
3. filtrationfiltered
4. concentrationconcentrated to dryness
5. customThis solid was purified column chromatography (silica, hexanes:ethyl acetate 4:1)
6. customthen re-crystallised from ethyl acetate