Hydroxyamine hydrochloride → HCID 24773357, compound

HRID 2097300Notes

Reaction equation

HRID 2097300 reaction equation
[CH2:1]([O:3][C:4](=[O:36])[C:5](=O)[CH2:6][C:7]([C:9]1[CH:14]=[C:13]([CH2:15][CH:16]([CH3:18])[CH3:17])[C:12]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:11][C:10]=1[O:27][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)=[O:8])[CH3:2].Cl.[NH2:38]O>C(O)C>[CH2:1]([O:3][C:4]([C:5]1[CH:6]=[C:7]([C:9]2[CH:14]=[C:13]([CH2:15][CH:16]([CH3:18])[CH3:17])[C:12]([O:19][CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[CH:11][C:10]=2[O:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[O:8][N:38]=1)=[O:36])[CH3:2]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 592647774-(2,4-Bis-benzyloxy-5-isobutyl-phenyl)-2,4-dioxo-butyric acid ethyl ester

Product 1

HCID 24773357HCID 24773357, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-(2,4-Bis-benzyloxy-5-isobutyl-phenyl)-2,4-dioxo-butyric acid ethyl ester (1 eq) was dissolved in ethanol with stirring. Hydroxylamine hydrochloride (1.2 eq) was added and the solution was heated to reflux for 2 hours. The reaction mixture was cooled to room temperature, to give a precipitate. This precipitate was obtained by filtration to give 5-(2,4-Bis-benzyloxy-5-isobutyl-phenyl)-isoxazole-3-carboxylic acid ethyl ester as a white solid.

Workup

  1. temperaturethe solution was heated
  2. temperatureto reflux for 2 hours
  3. customto give a precipitate
  4. customThis precipitate was obtained by filtration

Sources & evidence

ORD record
ord-f14a16330cec41499d539e572964fb09
Source dataset
uspto-grants-2013_05
Patent number
US08450310B2

Reaction notes

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