Acetic Acid → HCID 58732641, compound

HRID 2097314Notes

Reaction equation

HRID 2097314 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17](=[O:18])[C:16]3[C:11](=[CH:12][C:13]([OH:20])=[C:14]([Cl:19])[CH:15]=3)[O:10][CH:9]=2)=[CH:4][CH:3]=1.C1N2CN3CN(C2)CN1C3.Cl.O.[C:33](O)(=[O:35])C>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:17](=[O:18])[C:16]3[C:11](=[C:12]([CH:33]=[O:35])[C:13]([OH:20])=[C:14]([Cl:19])[CH:15]=3)[O:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

6

Reactant 5

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 962WaterHCID 4101HexamethylenetetramineHCID 58913628HCID 58913628, compound

Product 1

HCID 58732641HCID 58732641, compound

Conditions

Temperature
100 °C

Procedure

3-(4-Bromo-phenyl)-6-chloro-7-hydroxy-chromen-4-one (0.35 g, 1 mmol) and hexamethylene tetramine (0.14 g, 1 mmol) were dissolved in glacial acetic acid (20 ml) and heated overnight at 100° C. Warm 6M HCl (10 ml) was added and the mixture heated for a further hour before being poured in to water. The precipitate formed was filtered, washed and dried to provide the pure desired product as a pale brown solid.

Workup

  1. additionwas added
  2. temperaturethe mixture heated for a further hour
  3. customThe precipitate formed
  4. filtrationwas filtered
  5. washwashed
  6. customdried

Sources & evidence

ORD record
ord-f1a91208faed4481ba7e8e86bf62f27b
Source dataset
uspto-grants-2013_05
Patent number
US08450310B2

Reaction notes

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