3-(Pyridin-3-ylamino)-4-ethoxy-cyclobut-3-ene-1,2-dione → HCID 23132448, compound

HRID 2097346Notes

Reaction equation

HRID 2097346 reaction equation
C(O[C:4]1[C:5](=[O:16])[C:6](=[O:15])[C:7]=1[NH:8][C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)C.[O:17]1[CH2:22][CH2:21][N:20]([CH2:23][C:24]2[CH:37]=[CH:36][C:27]([O:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][NH2:35])=[CH:26][CH:25]=2)[CH2:19][CH2:18]1>C(O)C>[O:17]1[CH2:18][CH2:19][N:20]([CH2:23][C:24]2[CH:25]=[CH:26][C:27]([O:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][NH:35][C:4]3[C:5](=[O:16])[C:6](=[O:15])[C:7]=3[NH:8][C:9]3[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=3)=[CH:36][CH:37]=2)[CH2:21][CH2:22]1

Participants

4

Reactant 2

HCID 105129913-(Pyridin-3-ylamino)-4-ethoxy-cyclobut-3-ene-1,2-dioneHCID 231324366-[4-(Morpholinomethyl)phenoxy]hexylamine

Product 1

HCID 23132448HCID 23132448, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 3-ethoxy-4-(pyridin-3-yl-amino)-3-cyclobutene-1,2-dione (350 mg, 1.6 mmol) in ethanol (1.4 mL) was added 6-[4-(morpholinomethyl)-phenoxy]-hexylamine (469 mg, 1.6 mmol) in ethanol (5 mL). The reaction was allowed to stir at r.t. for 18 h, then filtered. The solid was washed with cold ethanol, then ether to give the title compound.

Workup

  1. filtrationfiltered
  2. washThe solid was washed with cold ethanol

Sources & evidence

ORD record
ord-e936ecd1e605432ba8c78f7144b0ac1e
Source dataset
uspto-grants-2013_05
Patent number
US08450348B2

Reaction notes

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