3-(Pyridin-3-ylamino)-4-ethoxy-cyclobut-3-ene-1,2-dione → 3-(6-[4-(Morpholinomethyl)-phenoxy]-hexylamino)-4-(pyridin-3-yl-amino)-3-cyclobutene-1,2-dione

Participants

Reaction Steps

To a solution of 3-ethoxy-4-(pyridin-3-yl-amino)-3-cyclobutene-1,2-dione (350 mg, 1.6 mmol) in ethanol (1.4 mL) was added 6-[4-(morpholinomethyl)-phenoxy]-hexylamine (469 mg, 1.6 mmol) in ethanol (5 mL). The reaction was allowed to stir at r.t. for 18 h, then filtered. The solid was washed with cold ethanol, then ether to give the title compound.

Provenance & Evidence