反应详情

温度

80 °C

NaN3 (390 mg, 6.0 mmol) was added to a solution of 7-bromoheptanol (880 μL, 5.7 mmol) in DMF (5 mL). The mixture was stirred for 24 at r.t. and additional 3 h at 80° C. to complete the reaction. The mixture was concentrated under reduced pressure, the residue was dissolved in water/Et2O (10/20 mL), the organic layer was separated, dried over Na2SO4 and filtered. Concentration under reduced pressure yielded 7-azidoheptanol (710 mg, 78%) as an colourless oil which was pure enough for further reactions.

1. customthe reaction
2. concentrationThe mixture was concentrated under reduced pressure
3. dissolutionthe residue was dissolved in water/Et2O (10/20 mL)
4. customthe organic layer was separated
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. concentrationConcentration under reduced pressure