反应详情

4-(Chloromethyl)-benzylalcohol (5.01 g, 32 mmol) and NaN3 (2.50 g, 38.4 mmol) were stirred in DMF (25 mL) at 90° C. for 17 h. The solvent was removed under reduced pressure and the residue was partitioned between water (50 mL) and Et2O (100 mL). The aqueous layer was extracted with Et2O (2×50 mL) and the combined org. layers were dried over Na2SO4. After filtration the solvent was removed under reduced pressure to give (4-azidomethyl-phenyl)-methanol, pure enough for further reaction.

1. customThe solvent was removed under reduced pressure
2. customthe residue was partitioned between water (50 mL) and Et2O (100 mL)
3. extractionThe aqueous layer was extracted with Et2O (2×50 mL)
4. dry with materiallayers were dried over Na2SO4
5. filtrationAfter filtration the solvent
6. customwas removed under reduced pressure