Ethanol → 4-[2-(Morpholin-4-yl)ethoxy]phenol

HRID 2097358Notes

Reaction equation

HRID 2097358 reaction equation
C(O[C:9]1[CH:23]=[CH:22][CH:21]=[CH:20][C:10]=1[O:11][CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)C1C=CC=CC=1.CC[OH:26]>[Pd]>[N:14]1([CH2:13][CH2:12][O:11][C:10]2[CH:20]=[CH:21][C:22]([OH:26])=[CH:23][CH:9]=2)[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 702Ethanol2×HCID 29954124-[2-(Benzyloxy-phenoxy)-ethyl]-morpholine

Product 1

HCID 231324384-[2-(Morpholin-4-yl)ethoxy]phenol

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A solution of 4-[2-(Benzyloxy-phenoxy)-ethyl]-morpholine (4.77 g, 15.2 mmol) in EtOH (35 mL) was added to palladium on carbon (250 mg) in EtOH (15 mL) under an atmosphere of Hydrogen. The mixture was stirred for 17 h at r.t. The mixture was filtered through celite and the solvent was removed under reduced pressure to give the title compound.

Workup

  1. filtrationThe mixture was filtered through celite
  2. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-0cc1817318d9413c9b25a1f6249a9104
Source dataset
uspto-grants-2013_05
Patent number
US08450348B2

Reaction notes

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