HCID 66602707, compound → 2-(3-Cyclopropoxy-4-difluoromethoxyphenyl)-3-(4-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one

HRID 2097403Notes

Reaction equation

HRID 2097403 reaction equation
C(OC[N:10]1[C:14]2[CH:15]=[N:16][NH:17][C:18](=[O:19])[C:13]=2[C:12]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)=[C:11]1[C:28]1[CH:33]=[CH:32][C:31]([O:34][CH:35]([F:37])[F:36])=[C:30]([O:38][CH:39]2[CH2:41][CH2:40]2)[CH:29]=1)C1C=CC=CC=1.C(OCN1C2C=NNC(=O)C=2C(CC2C=CC=CC=2F)=C1C1C=CC(OC(F)F)=C(OC2CC2)C=1)C1C=CC=CC=1>>[CH:39]1([O:38][C:30]2[CH:29]=[C:28]([C:11]3[NH:10][C:14]4[CH:15]=[N:16][NH:17][C:18](=[O:19])[C:13]=4[C:12]=3[CH2:20][C:21]3[CH:22]=[CH:23][C:24]([F:27])=[CH:25][CH:26]=3)[CH:33]=[CH:32][C:31]=2[O:34][CH:35]([F:37])[F:36])[CH2:41][CH2:40]1

Participants

3

Reactant 2

HCID 66602707HCID 66602707, compoundHCID 66602968HCID 66602968, compound

Product 1

HCID 1358450402-(3-Cyclopropoxy-4-difluoromethoxyphenyl)-3-(4-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-oneYield 29.4%

Procedure

Reaction and post treatment were carried out in the same manner as in Example 22-(b) except for using 184 mg (0.531 mmol) of 1-benzyloxymethyl-2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-(4-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one obtained in Example 24-(a) in place of 1-benzyloxymethyl-2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-(2-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one, whereby 69 mg of the title compound was obtained as a white solid. (Yield: 24%)

Workup

  1. customReaction and post treatment

Sources & evidence

ORD record
ord-7fa2af6b6a0a479687441faf64d73ccf
Source dataset
uspto-grants-2013_05
Patent number
US08450319B2

Reaction notes

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