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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2097403Generated: October 30, 2026

HCID 66602707, compound → 2-(3-Cyclopropoxy-4-difluoromethoxyphenyl)-3-(4-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one

https://huagongshe.com/reaction/2097403

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 66602707HCID 66602707—
ReactantHCID 66602968HCID 66602968—
Product2-(3-Cyclopropoxy-4-difluoromethoxyphenyl)-3-(4-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-oneHCID 13584504029.4%

Reaction Steps

Reaction and post treatment were carried out in the same manner as in Example 22-(b) except for using 184 mg (0.531 mmol) of 1-benzyloxymethyl-2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-(4-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one obtained in Example 24-(a) in place of 1-benzyloxymethyl-2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-(2-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one, whereby 69 mg of the title compound was obtained as a white solid. (Yield: 24%)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08450319B2
Source datasetuspto-grants-2013_05
ORD IDord-7fa2af6b6a0a479687441faf64d73ccf
Source noteuspto-grants-2013_05