HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 66602707, compound → 2-(3-Cyclopropoxy-4-difluoromethoxyphenyl)-3-(4-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 66602707 | HCID 66602707 | — |
| Reactant | HCID 66602968 | HCID 66602968 | — |
| Product | 2-(3-Cyclopropoxy-4-difluoromethoxyphenyl)-3-(4-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one | HCID 135845040 | 29.4% |
Reaction Steps
Reaction and post treatment were carried out in the same manner as in Example 22-(b) except for using 184 mg (0.531 mmol) of 1-benzyloxymethyl-2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-(4-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one obtained in Example 24-(a) in place of 1-benzyloxymethyl-2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-(2-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one, whereby 69 mg of the title compound was obtained as a white solid. (Yield: 24%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450319B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-7fa2af6b6a0a479687441faf64d73ccf |
| Source note | uspto-grants-2013_05 |