HCID 66602821, compound → 2-(3-Cyclopropoxy-4-difluoromethoxyphenyl)-3-dimethylaminomethyl-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one

HRID 2097410Notes

Reaction equation

HRID 2097410 reaction equation
[CH:1]1([O:4][C:5]2[CH:6]=[C:7]([C:15]3[N:24](COCC[Si](C)(C)C)[C:18]4[CH:19]=[N:20][NH:21][C:22](=[O:23])[C:17]=4[C:16]=3[CH2:33][N:34]([CH3:36])[CH3:35])[CH:8]=[CH:9][C:10]=2[O:11][CH:12]([F:14])[F:13])[CH2:3][CH2:2]1>O>[CH:1]1([O:4][C:5]2[CH:6]=[C:7]([C:15]3[NH:24][C:18]4[CH:19]=[N:20][NH:21][C:22](=[O:23])[C:17]=4[C:16]=3[CH2:33][N:34]([CH3:36])[CH3:35])[CH:8]=[CH:9][C:10]=2[O:11][CH:12]([F:13])[F:14])[CH2:2][CH2:3]1

Participants

3

Reactant 1

HCID 66602821HCID 66602821, compound

Product 1

HCID 1358450232-(3-Cyclopropoxy-4-difluoromethoxyphenyl)-3-dimethylaminomethyl-1,5-dihydropyrrolo[2,3-d]pyridazin-4-oneYield 68%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Reaction was carried out in the same manner as in Example 1-(b) except for using 70 mg (0.14 mmol) of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-dimethylaminomethyl-1-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one obtained in Example 30-(a) in place of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-1-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one. After completion of the reaction, water was added to the reaction mixture to precipitate a solid, and the precipitated solid was collected by filtration. The obtained solid was washed with water and dried under reduced pressure to obtain 36 mg of the title compound as a gray solid. (Yield: 68%)

Workup

  1. customReaction
  2. additionwas added to the reaction mixture
  3. customto precipitate a solid
  4. filtrationthe precipitated solid was collected by filtration
  5. washThe obtained solid was washed with water
  6. customdried under reduced pressure

Sources & evidence

ORD record
ord-ba7bbbabb7904899a2f35efdc9f77a42
Source dataset
uspto-grants-2013_05
Patent number
US08450319B2

Reaction notes

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