HCID 66602821, compound → 2-(3-Cyclopropoxy-4-difluoromethoxyphenyl)-3-dimethylaminomethyl-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one

Participants

Reaction Steps

Reaction was carried out in the same manner as in Example 1-(b) except for using 70 mg (0.14 mmol) of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-dimethylaminomethyl-1-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one obtained in Example 30-(a) in place of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-1-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one. After completion of the reaction, water was added to the reaction mixture to precipitate a solid, and the precipitated solid was collected by filtration. The obtained solid was washed with water and dried under reduced pressure to obtain 36 mg of the title compound as a gray solid. (Yield: 68%)

Provenance & Evidence