Isopropyl iodide → 4-Bromo-1-methoxy-2-[(propan-2-yl)oxy]benzene

HRID 2097471Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH3:10])=[C:6]([OH:8])[CH:7]=1.[CH:11](I)([CH3:13])[CH3:12]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH3:10])=[C:6]([O:8][CH:11]([CH3:13])[CH3:12])[CH:7]=1

Participants

Reactant 2

HCID 6362Isopropyl iodide

HCID 1422285-Bromo-2-methoxyphenol

Product 1

HCID 467389524-Bromo-1-methoxy-2-[(propan-2-yl)oxy]benzeneYield 86%

Procedure

Reaction and post treatment were carried out in the same manner as in Reference Example 7-(a) except for using 10.1 g (49.8 mmol) of 5-bromo-2-methoxyphenol, and using 15 ml of isopropyl iodide in place of 1-bromo-2-chloroethane, whereby 10.4 g of the title compound was obtained as a pale yellowish solid. (Yield: 86%)

Workup

customReaction and post treatment

Sources & evidence

ORD record: ord-a32da5b587a54276a8e4474713d739eb
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08450319B2

Reaction notes

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