HCID 66602679, compound → HCID 86627043, compound

HRID 2097510Notes

Reaction equation

HRID 2097510 reaction equation
[Br:1][C:2]1[N:19]([CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:27])([CH3:26])[CH3:25])[C:5]2[CH:6]=[N:7][N:8]([CH2:11][O:12][CH2:13][CH2:14][Si:15]([CH3:18])([CH3:17])[CH3:16])[C:9](=[O:10])[C:4]=2[C:3]=1[CH2:28]Br.BrC1N(COCC[Si](C)(C)C)C2C=NNC(=[O:39])C=2C=1CBr>>[Br:1][C:2]1[N:19]([CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:27])([CH3:25])[CH3:26])[C:5]2[CH:6]=[N:7][N:8]([CH2:11][O:12][CH2:13][CH2:14][Si:15]([CH3:18])([CH3:16])[CH3:17])[C:9](=[O:10])[C:4]=2[C:3]=1[CH:28]=[O:39]

Participants

3

Reactant 2

HCID 66602679HCID 66602679, compoundHCID 66602907HCID 66602907, compound

Product 1

HCID 86627043HCID 86627043, compoundYield 67%

Procedure

Reaction and post treatment were carried out in the same manner as in Reference example 24-(g) except for using 5.70 g (10.0 mmol) of 2-bromo-3-bromomethyl-1,5-bis(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one obtained in Reference example 25-(a) in place of 2-bromo-3-bromomethyl-1-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one, whereby 3.38 g of the title compound was obtained as a white solid. (Yield: 67%)

Workup

  1. customReaction and post treatment

Sources & evidence

ORD record
ord-2c65fb10255646389de2cd58983d4f71
Source dataset
uspto-grants-2013_05
Patent number
US08450319B2

Reaction notes

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