Iodoethane → HCID 66602781, compound

HRID 2097549Notes

Reaction equation

[OH:1][CH2:2][CH2:3][C:4]1[C:12]2[C:11](=[O:13])[N:10]([CH2:14][O:15][CH2:16][CH2:17][Si:18]([CH3:21])([CH3:20])[CH3:19])[N:9]=[CH:8][C:7]=2[N:6]([CH2:22][O:23][CH2:24][CH2:25][Si:26]([CH3:29])([CH3:28])[CH3:27])[CH:5]=1.[CH2:30](I)[CH3:31]>>[CH2:30]([O:1][CH2:2][CH2:3][C:4]1[C:12]2[C:11](=[O:13])[N:10]([CH2:14][O:15][CH2:16][CH2:17][Si:18]([CH3:19])([CH3:20])[CH3:21])[N:9]=[CH:8][C:7]=2[N:6]([CH2:22][O:23][CH2:24][CH2:25][Si:26]([CH3:28])([CH3:27])[CH3:29])[CH:5]=1)[CH3:31]

Participants

Reactant 2

HCID 6340Iodoethane

HCID 66602683HCID 66602683, compound

Product 1

HCID 66602781HCID 66602781, compoundYield 63.1%

Procedure

Reaction and post treatment were carried out in the same manner as in Reference example 57-(f) except for using 1.15 g (2.61 mmol) of 3-(2-hydroxyethyl)-1,5-bis(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one obtained by the same manner as in Reference example 57-(e), and using 1.3 ml (18.7 mmol) of ethyl iodide in place of methyl iodide, whereby 0.77 g of the title compound was obtained as a slightly yellowish oil. (Yield: 63%)

Workup

customReaction and post treatment

Sources & evidence

ORD record: ord-5c90df9a9ee348d0959754913e167726
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08450319B2

Reaction notes

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