反应详情

温度

120 °C

2-chloro-5-hydroxyphenyl boronic acid (409 mg, 2.37 mmol), pinacol (336 mg, 2.85 mmol), toluene (20 ml) and 4 angstrom molecular sieves (400 mg) were combined and heated at 120° C. for 2 h. The reaction mixture was allowed to cool and was then partitioned between EtOAc (2×30 ml) and water (30 ml). The combined organics were washed with brine (20 ml), dried (Na2SO4) and evaporated in vacuo to afford the desired product as a white solid (500 mg, 83%).

1. temperatureto cool
2. customwas then partitioned between EtOAc (2×30 ml) and water (30 ml)
3. washThe combined organics were washed with brine (20 ml)
4. dry with materialdried (Na2SO4)
5. customevaporated in vacuo