Trifluoroacetic acid → (Quinolin-8-yl)acetic acid

HRID 2097962Notes

Reaction equation

HRID 2097962 reaction equation
Br[C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.[C:12]([OH:18])([C:14](F)(F)F)=[O:13]>>[N:10]1[C:11]2[C:6](=[CH:5][CH:4]=[CH:3][C:2]=2[CH2:14][C:12]([OH:18])=[O:13])[CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 1401098-Bromoquinoline

Product 1

HCID 16227542(Quinolin-8-yl)acetic acid

Procedure

The title compound (278 mg) was prepared from 8-bromoquinoline (3.0 g, 14.5 mmol) according to protocol P above. LCMS (0.05% TFA): [M+1]+ 188.1. 1H-NMR (CD3OD, 400 MHz): δ 9.01 (d, 1H, J=3.6 Hz), 8.72 (d, 1H, J=6.4 Hz), 8.06 (d, 1H, J=6.8 Hz), 7.87 (d, 1H, J=5.6 Hz), 7.77 (m, 2H), 4.31 (s, 2H).

Sources & evidence

ORD record
ord-da6614a255c74158b3c3674d4ae774dd
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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