HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2097967Generated: October 26, 2026
Hydrochloric Acid → 3-(2-(Naphthalen-1-yl)acetamido)thiophene-2-carboxylic acid
https://huagongshe.com/reaction/2097967
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 3-(2-(naphthalen-1-yl)acetamido)thiophene-2-carboxylate | HCID 25660569 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | 3-(2-(Naphthalen-1-yl)acetamido)thiophene-2-carboxylic acid | HCID 68755623 | — |
Reaction Steps
Methyl 3-(2-(naphthalen-1-yl)acetamido)thiophene-2-carboxylate (210 mg, 0.645 mmol) was dissolved in THF/H2O (2.5 mL, 4/1, v/v). Sodium hydroxide (129 mg, 3.22 mmol) was added and the reaction mixture was stirred at 50° C. for 20 h. The resulting solution was acidified with 10% aqueous HCl and extracted with ethyl acetate. The organic phase was separated, dried (Na2SO4), filtered and concentrated under vacuum to give 3-(2-(naphthalen-1-yl)acetamido)thiophene-2-carboxylic acid. Retention time=1.962 min, method [1], MS (ESI) 312.1 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08450363B2 |
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| Source dataset | uspto-grants-2013_05 |
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| ORD ID | ord-0a0c47eba8524ae6b01ecee2941abd0f |
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| Source note | uspto-grants-2013_05 |
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