Dimethylformamide → HCID 178434590、化合物
反応式
[CH3:1][C:2]1[C:3]([C:21]([NH2:23])=O)=[C:4]([NH:7][C:8](=[O:20])[CH2:9][C:10]2[CH:19]=[CH:18][CH:17]=[C:16]3[C:11]=2[N:12]=[CH:13][CH:14]=[N:15]3)[S:5][CH:6]=1.C[N:25](C=O)C.NN.[CH3:31][C:32]([N:34](C)C)=O.CC(N(C)C)=O>>[CH3:1][C:2]1[C:3]([C:21]2[NH:23][N:34]=[C:32]([CH3:31])[N:25]=2)=[C:4]([NH:7][C:8](=[O:20])[CH2:9][C:10]2[CH:19]=[CH:18][CH:17]=[C:16]3[C:11]=2[N:12]=[CH:13][CH:14]=[N:15]3)[S:5][CH:6]=1参加物
5
反応条件
- 温度
- 90 °C
実験手順
This analog was made from 4-methyl-2-(2-(quinoxalin-5-yl)acetamido)thiophene-3-carboxamide using protocol D except that the DMF was also used in the DMA-DMA step with heating to 95° C. (rather than 110° C.) and the hydrazine step was heated at 95° C. (rather than 90° C.). Method[7], MS (ESI) 365.1 [M+H], Retention time=3.58 min; 1H-NMR (300 MHz, CDCl3) δ 11.9 (s, 1H), 8.87 (s, 2H), 8.17-8.14 (m, 1H), 7.92-7.83 (m, 2H), 6.50 (s, 1H), 4.53 (s, 2H), 2.45 (s, 3H), 2.30 (s, 3H).
出典と根拠
- ORDレコード
- ord-e6ea72bba4ad40ffb6ae644b902c7a86
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08450363B2
反応ノート
読み込み中…