関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Hydrazine | HCID 9321 | — |
| 反応物 | DMA dimethylacetamide | HCID 19097097 | — |
| 反応物 | 4-Methyl-2-(2-(quinoxalin-5-yl)acetamido)thiophene-3-carboxamide | HCID 68756207 | — |
| 生成物 | HCID 178434590 | HCID 178434590 | — |
反応手順
This analog was made from 4-methyl-2-(2-(quinoxalin-5-yl)acetamido)thiophene-3-carboxamide using protocol D except that the DMF was also used in the DMA-DMA step with heating to 95° C. (rather than 110° C.) and the hydrazine step was heated at 95° C. (rather than 90° C.). Method[7], MS (ESI) 365.1 [M+H], Retention time=3.58 min; 1H-NMR (300 MHz, CDCl3) δ 11.9 (s, 1H), 8.87 (s, 2H), 8.17-8.14 (m, 1H), 7.92-7.83 (m, 2H), 6.50 (s, 1H), 4.53 (s, 2H), 2.45 (s, 3H), 2.30 (s, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08450363B2 |
|---|
| 出典データセット | uspto-grants-2013_05 |
|---|
| ORD ID | ord-e6ea72bba4ad40ffb6ae644b902c7a86 |
|---|
| 出典メモ | uspto-grants-2013_05 |
|---|
