4-bromo-3-(4H-1,2,4-triazol-3-yl)thiophen-2-amine → HCID 56665246, compound

HRID 2098020Notes

Reaction equation

HRID 2098020 reaction equation
[O:1]=[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][C:6]([C:12]([F:15])([F:14])[F:13])=[N:7][CH:8]=2)[N:3]1[CH2:16][C:17]([OH:19])=O.[Br:20][C:21]1[C:22]([C:27]2[NH:31][N:30]=[CH:29][N:28]=2)=[C:23]([NH2:26])[S:24][CH:25]=1>>[Br:20][C:21]1[C:22]([C:27]2[NH:31][N:30]=[CH:29][N:28]=2)=[C:23]([NH:26][C:17](=[O:19])[CH2:16][N:3]2[C:4]3[C:9](=[CH:8][N:7]=[C:6]([C:12]([F:13])([F:14])[F:15])[CH:5]=3)[CH:10]=[CH:11][C:2]2=[O:1])[S:24][CH:25]=1

Participants

3

Reactant 2

HCID 596366864-bromo-3-(4H-1,2,4-triazol-3-yl)thiophen-2-amineHCID 68785189HCID 68785189, compound

Product 1

HCID 56665246HCID 56665246, compound

Procedure

The title compound was prepared from 2-(2-oxo-7-(trifluoromethyl)-1,6-naphthyridin-1(2H)-yl)acetic acid (55 mg, 0.203 mmol) and 4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-amine (25 mg, 0.102 mmol) according to protocol A. Retention time (min)=4.505, method [7], MS (ESI) 499.0 (M+H); 1H NMR (300 MHz, CD3OD) δ 9.06 (s, 1H), 8.31 (s, 1H), 8.24 (d, J=9.4 Hz, 1H), 7.94 (s, 1H), 7.14 (s, 1H), 6.99 (d, J=9.4 Hz, 1H), 5.39 (s, 2H).

Sources & evidence

ORD record
ord-7cb2fde21c8941c1b9e64f8e426b5d74
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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