Hydrochloric Acid → 2-(2-(Trifluoromethyl)quinolin-7-yl)acetic acid

HRID 2098063Notes

Reaction equation

HRID 2098063 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][C:7]([CH2:13][C:14]([O:16]C(C)(C)C)=[O:15])=[CH:8][CH:9]=2)[N:4]=1.Cl>CC(O)=O>[F:22][C:2]([F:1])([F:21])[C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][C:7]([CH2:13][C:14]([OH:16])=[O:15])=[CH:8][CH:9]=2)[N:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86649421tert-Butyl 2-(2-(trifluoromethyl)quinolin-7-yl)acetate

Product 1

HCID 687547832-(2-(Trifluoromethyl)quinolin-7-yl)acetic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

tert-Butyl 2-(2-(trifluoromethyl)quinolin-7-yl)acetate was dissolved in glacial AcOH (0.8 mL) and 6 N HCl (0.8 mL) and heated to 80° C. for 2 hr. The reaction mixture was concentrated in vacuo to afford the crude product, which was used without further purification. HPLC method [4], retention time=1.874 min; MS (ESI) 256.1 (MH+).

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-7b21cf9bdb804b4189486eb042ffad97
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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